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Direct HIV detection for infants soon
At present, millions of children face death and stunted growth due to late diagnosis
Aditi Tandon
Tribune News Service

Chandigarh, November 30
HIV positive mothers will no longer have to wait for their infants to reach 18 months of age to find out if they too are carrying the human immunodeficiency virus.

In what can be called a World AIDS Day gift to millions of estimated HIV positive infants across the country that face risk of death and developmental delays due to late diagnosis, the Government of India is moving fast to implement the world’s most sophisticated direct HIV detection test for infants and save them from dying due to delayed detection. India will be the first country in south and Southeast Asia to introduce this test, mainly implemented in Africa till now.

Called DNA PCR (polymerase chain reaction), this effective facility uses dried blood spots from a baby to determine his HIV status by the time he is 8 weeks old. The process involves amplification of his DNA. The test is far ahead in technology to the usual HIV antibody test used till now. The latter gives no definitive results till the child is 18 month-old. But the new test saves precious time and prevents infant mortality as an infected child can be straightaway put on antiretroviral therapy (ART). Among all patients of HIV, children respond best to ART.

The move assumes significance as 2.9 per cent of the 2.47 million estimated HIV cases in India are children; further, HIV positive infants are the most vulnerable of HIV patients. Fifty per cent untreated infected children die by the time they are 2; 80 per cent die by the time they are 5.

But pediatric HIV detection will now change, with the health ministry procuring DNA PCR testing kits from Rouche, the only international firm marketing them. The kits are being validated for quality assurance at the National HIV/AIDS Research laboratory, Pune.

“Validation is needed for the kits to be approved by the drug controller of India. We have meanwhile completed capacity building of doctors who have been trained by the Clinton Foundation. National reference labs are ready for new testing and we have identified state-level centres where dried blood samples of infants will be collected,” Dr Tripti Bensi, national programme coordinator, paediatric care, NACO, today informed the Tribune. She said DNA PCR is a very costly test but recently its international prices came down.

Until now, doctors in India have been using the HIV antibody (or ELISA) test to determine HIV among infants. But this test has limitations. Dr Bensi, explains: “Diagnosis through antibody test is difficult due to presence of maternal HIV antibodies among infants. These antibodies get transferred from mother to child during pregnancy, childbirth and breastfeeding.”

‘Most infants born to HIV positive mothers test positive using the antibody test, which is not definitive till the time infant is 18 month-old. It is then that the level of maternal antibodies in a child falls below the limit of detection, and we can know if he is infected. Till then, treatment can’t be given.” Results are damaging - 47 per cent HIV positive children below 18 months become stunted; 20 per cent die in the first year of life. But that’s set to change.

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