Thursday, November 23, 2017
facebook

google plus
Health

Posted at: Sep 14, 2017, 1:15 PM; last updated: Sep 14, 2017, 1:15 PM (IST)

Fast paper-based tuberculosis test developed

Fast paper-based tuberculosis test developed
Diagnosing tuberculosis (TB) early can allow patients to receive the medicine they need and also help prevent the disease from spreading.

Beijing

Scientists have developed a fast, paper-based test to diagnose tuberculosis that can be read with a smartphone, a technology that is increasingly available in emerging economies.

Diagnosing tuberculosis (TB) early can allow patients to receive the medicine they need and also help prevent the disease from spreading.

However, in resource-limited areas, equipment requirements and long wait times for results are obstacles to diagnosis and treatment.

To tackle this problem, Chien-Fu Chen from National Taiwan University and colleagues come up with a more practical diagnostic test that can be read with a smartphone.

The researchers combined gold nanoparticles with fluorescent single-stranded DNA sequences that bind to the genetic material of Mycobacterium tuberculosis, the bacteria that cause TB.

These nanoparticles were then incorporated into a paper- based device. Adding even a minute amount of lab-derived, double-stranded DNA from M tuberculosis changed the colour of the test spots within an hour.

A smartphone camera was used to analyse the colour change to determine the bacterial concentration.

The researchers also tested a tissue sample from an infected patient to further demonstrate that the device could be used in the field.

The World Health Organization (WHO) estimates that in 2015, 1.4 million people died from TB, with most of these deaths occurring in low- and middle-income countries, researchers said.

Early diagnosis could help curb these numbers. However, conventional methods such as sputum smear microscopy, chest X-rays and molecular-based tests require equipment, electricity and specialised personnel that are not always available in remote or developing areas.

The research was published in the journal ACS Sensors.

—PTI

COMMENTS

All readers are invited to post comments responsibly. Any messages with foul language or inciting hatred will be deleted. Comments with all capital letters will also be deleted. Readers are encouraged to flag the comments they feel are inappropriate.
The views expressed in the Comments section are of the individuals writing the post. The Tribune does not endorse or support the views in these posts in any manner.
Share On