Four cups of coffee daily may help protect your heart : The Tribune India

Join Whatsapp Channel

Four cups of coffee daily may help protect your heart

BERLIN: Drinking about four cups of coffee everyday can protect you from heart diseases, say scientists who have found that caffeine promotes the movement of a regulatory protein into mitochondria, enhancing their function and protecting cardiovascular cells from damage.

Four cups of coffee daily may help protect your heart

Photo source: Thinkstock



Berlin

Drinking about four cups of coffee everyday can protect you from heart diseases, say scientists who have found that caffeine promotes the movement of a regulatory protein into mitochondria, enhancing their function and protecting cardiovascular cells from damage.

Caffeine consumption has been associated with lower risks for multiple diseases, including type II diabetes, heart disease, and stroke, but the mechanism underlying these protective effects has been unclear.

The study, published in the journal PLOS Biology, a protein called p27, known mainly as an inhibitor of the cell cycle, was present in mitochondria in the major cell types of the heart.

In these cells, mitochondrial p27 promoted migration of endothelial cells, protected heart muscle cells from cell death, and triggered the conversion of fibroblasts into cells containing contractile fibers -- all crucial for repair of heart muscle after myocardial infarction.

Researchers, including those from IUF-Leibniz Research Institute for Environmental Medicine in Germany, found that caffeine induced the movement of p27 into mitochondria, setting off this beneficial chain of events, and did so at a concentration that is reached in humans by drinking four cups of coffee.

Caffeine was protective against heart damage in pre-diabetic, obese mice, and in aged mice.

Researchers said that in humans, the protective effect was reached at a concentration equivalent to consumption of four cups of coffee, suggesting the effect may be physiologically relevant.   

"Our results indicate a new mode of action for caffeine, one that promotes protection and repair of heart muscle through the action of mitochondrial p27," said Judith Haendeler, from Heinrich-Heine-University in Germany.

"These results should lead to better strategies for protecting heart muscle from damage, including consideration of coffee consumption or caffeine as an additional dietary factor in the elderly population," said Haendeler.

"Furthermore, enhancing mitochondrial p27 could serve as a potential therapeutic strategy not only in cardiovascular diseases but also in improving healthspan," she said. PTI

Top News

Supreme Court asks Centre to respond within 3 weeks to pleas seeking stay of CAA

Supreme Court asks Centre to respond to petitions seeking stay on implementation of CAA

A bench headed by Chief Justice D Y Chandrachud posted the m...

Raj Thackeray meets Home Minister Amit Shah ‘to keep Uddhav Thackeray factor’ at bay

Raj Thackeray meets Home Minister Amit Shah ‘to keep Uddhav Thackeray factor’ at bay

If the alliance is sealed, the MNS may be given one seat to ...

Ex-Indian ambassador to US Taranjit Singh Sandhu joins BJP

Ex-Indian ambassador to US Taranjit Singh Sandhu joins BJP, to contest Amritsar Lok Sabha seat

With Sandhu in the fray, BJP hopes to win back Amritsar wher...


Cities

View All