Fighting Covid

Scientists develop "ultrapotent" COVID-19 vaccine candidate

Scientists develop "ultrapotent" COVID-19 vaccine candidate

Washington, November 3

Scientists have developed a vaccine candidate for COVID-19 that produces “extremely high levels” of protective antibodies in animal models, an advance that may lead to a novel therapeutic to curb the pandemic.

According to the researchers, including those from the University of Washington (UW) School of Medicine in the US, the nanoparticle vaccine produces virus-neutralising antibodies in mice at levels much greater than is seen in people who have recovered from the disease.

The study, published in the journal Cell, noted that it generates ten times more neutralising antibodies in mice, even at a six-fold lower vaccine dose, and also shows a strong B-cell immune response after administration, which can be critical for a durable vaccine effect.

When a single non-human primate was immunised with the vaccine, the scientists said the candidate therapeutic produced neutralising antibodies targeting multiple different sites on the spike protein of the coronavirus, which it uses to enter human cells.

They said this may ensure protection against mutated strains of the virus, should they arise.

According to the study, the molecular structure of the vaccine roughly mimics that of a virus, which may account for its enhanced ability to provoke an immune response.

“We hope that our nanoparticle platform may help fight this pandemic that is causing so much damage to our world,” said Neil King, a co-author of the study from UW Medicine.

“The potency, stability, and manufacturability of this vaccine candidate differentiate it from many others under investigation,” King said. PTI 

Tribune Shorts

Top Stories

NCB official demanded Rs 25 cr from Shah Rukh Khan to release Aryan, alleges witness; agency denies claim

NCB official demanded Rs 25 cr from Shah Rukh Khan to release Aryan, alleges witness; agency denies claim

Was asked to sign nine to ten blank papers, claims ‘independ...

T20 World Cup: Babar Azam leads from front, ruthless Pakistan break India jinx

T20 World Cup: Babar Azam leads from front, ruthless Pakistan break India jinx

Babar remained not out on 68, while Rizwan made an unbeaten ...

Nobody will be allowed to disrupt peace and development in J-K: Amit Shah

Nobody will be allowed to disrupt peace and development in J-K: Amit Shah

Says time for sidelining people of Jammu has come to an end

Poonch operation: Arrested Pak terrorist killed, three security personnel injured

Poonch operation: Arrested Pak terrorist killed, three security personnel injured

Search ops enter 14th day, nine Army personnel have lost the...

Navjot Singh Sidhu: Let's focus on real issues

Navjot Singh Sidhu: Let's focus on real issues

The choice is clear between irreparable damage and the last ...

Cities

View All