IISc scientists develop new approach to potentially detect and kill cancer cells

Bengaluru, September 12

Scientists at the Indian Institute of Science (IISc) have developed a new approach to potentially detect and kill cancer cells, especially those which form a solid tumour mass.

They have created hybrid nanoparticles made of gold and copper sulphide, which can kill cancer cells using heat, and enable their detection using sound waves, according to a study published in ‘ACS Applied Nano Materials’.

Early detection and treatment are key in the battle against cancer, noted the Bengaluru-based IISc in a statement on Monday. Copper sulphide nanoparticles have previously received attention for their application in cancer diagnosis, while gold nanoparticles, which can be chemically modified to target cancer cells, have shown anti-cancer effects.

In the current study, the IISc team decided to combine these two into hybrid nanoparticles.

“These particles have photothermal, oxidative stress, and photoacoustic properties,” says Jaya Prakash, Assistant Professor at the Department of Instrumentation and Applied Physics, IISc, and one of the corresponding authors of the paper. PhD students Madhavi Tripathi and Swathi Padmanabhan are co-first authors.

When light is shone on these hybrid nanoparticles, they absorb the light and generate heat, which can kill cancer cells. These nanoparticles also produce singlet oxygen atoms that are toxic for the cells, the release pointed out. “We want both these mechanisms to kill the cancer cell,” Jaya Prakash explains.

The researchers say the nanoparticles can also help diagnose certain cancers.