Aging men with low testosterone levels who take testosterone replacement therapy (TRT) are at a greater risk of experiencing an ischemic stroke or a cardiac arrest especially during the first two years of use, warn researchers.
Published in The American Journal of Medicine, the findings confirm concerns voiced by many health agencies about the potential risks associated with the treatment.
"Our findings show that the use of TRT was associated with an increased risk of stroke, transient ischemic attack or cardiac arrest during the first two years of use," said Christel Renoux from the McGill University in Canada.
According to researchers, there is limited evidence on the long-term clinical benefits of TRT to effectively treat the modestly declining levels of endogenous testosterone levels of aging but healthy men.
"We strongly recommend that clinicians proceed with caution when considering prescribing TRT and first discuss both the potential benefits and risks with patients," Renoux said.
The study analysed a large database of electronic medical records of patients enrolled in primary care practices in the UK and formed a cohort of 15,401 men, aged 45 years or older, with low testosterone levels (hypogonadism).
Users of TRT had a 21 per cent greater risk of cardiovascular events compared with non-users, corresponding to an additional 128 events.
The increased risk appears to be transient, declining after two years of TRT use, which the investigators attribute to a phenomenon called "depletion of susceptible". — IANS
All readers are invited to post comments responsibly. Any messages with foul language or inciting hatred will be deleted. Comments with all capital letters will also be deleted. Readers are encouraged to flag the comments they feel are inappropriate. The views expressed in the Comments section are of the individuals writing the post. The Tribune does not endorse or support the views in these posts in any manner.
CJI-led Bench reserves verdict on review plea of woman who a...
On his 150th birth anniv, family members want govt to step i...
Book stall set up at the venue; two plays staged to mark occ...
Councillors across parties protest against stray catttle men...
Block GT Road on Day 3 of protest; submit memo to SDM
34 two-wheelers, including 13 Bullet motorcycles, recovered
Estimates, with minor changes, will be sent to UT Admn
Were going on bike to celebrate their success in 2nd-yr MBBS...
Two brothers had spent Rs1.35 cr for new building, flooring,...
Offenders to face cancellation of passports & licences