Study finds fragmented sleep patterns can predict vulnerability to chronic stress

Study finds fragmented sleep patterns can predict vulnerability to chronic stress

Photo for representation only. iStock

Abu Dhabi, January 12

New research from NYU Abu Dhabi's Laboratory of Neural Systems and Behavior for the first time used an animal model to demonstrate how abnormal sleep architecture can be a predictor of stress vulnerability.

These important findings have the potential to inform the development of sleep tests that can help identify who may be susceptible -- or resilient -- to future stress. In the study, Abnormal Sleep Signals Vulnerability to Chronic Social Defeat Stress, which appears in the journal Frontiers in Neuroscience, NYUAD Assistant Professor of Biology Dipesh Chaudhury and Research Associate Basma Radwan describe their development of a mouse model to detect how disruptions in Non-rapid Eye Movement (NREM) sleep result in increased vulnerability to future stress.

The researchers assessed the sleep characteristics of both stress-susceptible and stress-resilient mice before and after experiencing chronic social defeat (CSD) stress. The social behaviour of the mice post-stress was classified into two main phenotypes: those susceptible to stress that displayed social avoidance and those that were resilient to stress. Pre-CSD, mice susceptible to stress displayed increased fragmentation of Non-Rapid Eye Movement (NREM) sleep due to increased switching between NREM and wake and shorter average duration of NREM bouts, relative to mice resilient to stress.

Their analysis showed that the pre-CSD sleep features from both phenotypes of mice allowed prediction of susceptibility to stress with more than 80 per cent accuracy. Post-CSD, susceptible mice maintained high NREM fragmentation during the light and dark phase while resilient mice exhibited high NREM fragmentation only in the dark.

The findings demonstrate that mice that become susceptible to CSD stress exhibit pre-existing abnormal sleep/wake characteristics prior to stress exposure. In addition, subsequent exposure to stress further impairs sleep and the homeostatic response.

"Our study is the first to provide an animal model to investigate the relationship between poor sleep continuity and vulnerability to chronic stress and depressive disorders," said Chaudhury and Radwan. "This marker of vulnerability to stress opens up avenues for many possible future studies that could further explain the underlying molecular processes and neural circuitry that lead to mood disorders." - ANI

Don't Miss

Tracing the origins of Pashmina

Tracing the origins of Pashmina

Up against issues of racism Down Under

Up against issues of racism Down Under

Why we need to mock ourselves a little, reset our systems

Why we need to mock ourselves a little, reset our systems

Trump’s coup de tweet

Trump’s coup de tweet

Respect every opinion

Respect every opinion

Top Stories

Youngsters script India’s remarkable 3-wicket win in Brisbane

Youngsters script India’s remarkable 3-wicket win in Brisbane

Shubman Gill scores a brilliant 91, Rishabh Pant 89 not out

Farmers say they’ll hold peaceful tractor rally on Jan 26 in Delhi and won’t compromise on it

Farmers say they’ll hold peaceful tractor rally on Jan 26 in Delhi and won’t compromise on it

Union leader Balbir Singh Rajewal says the plan they have pr...

15 migrant workers killed as truck runs them over in Gujarat’s Surat

15 migrant workers killed as truck runs them over in Gujarat’s Surat

All those killed hailed from Rajasthan and were sleeping by ...

Nation sees lowest Covid cases in 7 months

Nation sees lowest Covid cases in 7 months

The country’s death toll increased to 1,52,556 with 137 fata...

Covishield not to be taken by people severely allergic to any of its ingredients: Serum Institute

Covishield not to be taken by people severely allergic to any of its ingredients: Serum Institute

‘Recipient should tell healthcare provider about all medical...

Cities

View All