Symptom and viral rebound rare after untreated COVID-19 infection: Study : The Tribune India

Symptom and viral rebound rare after untreated COVID-19 infection: Study

Symptom and viral rebound rare after untreated COVID-19 infection: Study

Photo for representation only.



PTI

Washington, February 21

A combination of symptom and viral rebound after untreated COVID-19 infection is rare, occurring in only three per cent of study participants, an analysis of a COVID-19 trial has found.

Widespread use of nirmatrelvir -- a recommended treatment for outpatients with mild to moderate COVID-19 -- has been accompanied by reports of worsening symptoms and virologic rebound after treatment completion, the researchers said.

Virologic rebound has also been reported in persons who did not receive nirmatrelvir therapy, they said.

However, studies that can define the frequencies of symptom and viral rebound during the natural course of COVID-19 are lacking.

Researchers from Brigham and Women's Hospital in the US conducted an analysis of 563 participants receiving placebo in a trial.

The study, published in the journal Annals of Internal Medicine, found that a combination of symptom and high-level viral rebound occurred in only three per cent of participants.

Symptom rebound alone occurred in 26 per cent of participants 11 days after initial symptom onset and viral rebound alone occurred in 31 per cent of participants, the researchers said.

High-level viral rebound was observed in 13 per cent of participants, they said.

The researchers noted that both symptom and viral rebound were short, lasting only one day in most participants.

These results highlight the importance of accounting for underlying rates of symptom relapse in the absence of antiviral therapy when evaluating the effects of antiviral treatments, they added.

Tribune Shorts


Top News

Odisha train crash LIVE updated: Accident one of deadliest in Indian Railways history; 233 dead

Odisha train crash LIVE update: 238 killed, 650 injured in one of the deadliest train accidents

Railway minister Vaishnaw visits accident site; says main fo...

Midnight hoax bomb call near Golden Temple puts Amritsar police on alert

Midnight hoax bomb call near Golden Temple puts Amritsar police on alert

Though no bomb was found, the police have taken four persons...

4 from Haryana’s Jind die in road accident on Panipat-Hardwar road

4 from Haryana’s Jind die in road accident on Panipat-Hardwar road

As many as 28 people of Kamach Khera village of Julana in Ji...

5.5 kg drugs dropped by drone seized near border in Amritsar sector

5.5 kg drugs dropped by drone seized near border in Amritsar sector

On the intervening night of June 2 -3, BSF troops deployed i...

Trafficking  trail: 27 agents booked, but only 4 arrested

Trafficking trail: 27 agents booked, but only 4 arrested

Many fled abroad | Cops to issue lookout circular


Cities

View All