US-based firm leads COVID-19 vaccine race, clinical trials show promising early results: Experts

New Delhi, May 20

As scientists across the world work frantically to find a vaccine against COVID-19, which continues its rapid global spread, all eyes are on US-based company Moderna’s encouraging early results on a small group of healthy volunteers.

Cautioning that a vaccine is still months, maybe even a year away, experts said the US-based biotechnology firm‘s results have propelled it to a pole position in the race of 118, say experts.

Eight candidate vaccines for COVID-19 are in the clinical evaluation, while 110 are in the preclinical stage, according to the WHO’s latest draft landscape.  Preclinical development is a stage of research during which important feasibility, iterative testing and drug safety data are collected, while clinical trials are research studies performed on people.

Early data from its vaccine candidate “mRNA-1273” showed it produced protective antibodies in a group of eight healthy volunteers, Moderna said.

The other closely watched COVID-19 vaccine is the one being developed by scientists at Oxford University. It appears protective in a small study of six monkeys, promising findings that led to the start of human trials late last month.

“Because Moderna’s is the only vaccine having demonstrated any kind of immunologic response in the COVID-19 field, we would consider this to be the leading candidate,” said Michael Breen, associate director, Infectious Disease, at GlobalData, a UK-based data analytics and consulting company.

“Of the vaccines in human trials, only two have demonstrated any kind of effectiveness,” Breen told PTI, noting that the Moderna study proves that the platform can lead to the production of antibodies against a given virus.

Moderna on Monday announced positive interim clinical data of mRNA-1273, from the Phase 1 study led by the National Institute of Allergy and Infectious Diseases (NIAID).

The data comes from eight people who took part in a 45-subject safety trial that kicked off in March.

The study showed the vaccine was safe and all study participants produced antibodies against the virus, according to the company.

“Globally, one vaccine candidate that is promising is Moderna’s mRNA based vaccine that showed promising results in the early trials,” Upasana Ray, assistant professor at CSIR-Indian Institute of Chemical Biology in Kolkata, told PTI.

RNA is the genetic material of the viruses. While conventional vaccines are developed with an inactivated virus or using proteins made by virus, messenger RNA (mRNA) vaccines work by introducing a synthetic sequence of the viruses’ genetic material that encodes the disease-specific protein to trigger the body’s immune system, the experts explained.

Discussing the Oxford University vaccine, she said the work “deserves applause but needs additional supportive information and experiments”.

The preliminary findings of the Oxford study appeared on the preprint server bioRxiv.

A preprint is a full draft research paper that is shared publicly before it has been peer reviewed or published in a journal.

British drug maker AstraZeneca teamed up with researchers at the Oxford Vaccine Group and the Jenner Institute in developing the vaccine.

Breen described their “ChAdOx1 nCoV-19” candidate vaccine as a “standout”. “While this vaccine has yet to demonstrate efficacy in humans, it was shown to be able to prevent infection and disease from COVID-19 in a primate model,” he said.

While this needs to be replicated in humans, it is one of only two vaccines to have demonstrated any effectiveness in reducing infection due to COVID-19, making it a “highly interesting candidate”.

Though the Moderna and the Oxford vaccines are in a leading position, there are several other vaccines, including those being developed in India, in the running.

In India, eight organisations are in the fray with a vaccine candidate, half of which are companies and the other half non-industry, said Brooke Wilson, associate director, Healthcare, GlobalData.

“These organisations are running or planning to initiate 12 clinical trials, one is ongoing, recruiting and the other 11 are planned,” Wilson told PTI.

He explained that six of these trials are specifically for a COVID-19 vaccine while the other six trials use a vaccine developed for other indications, such as tuberculosis, adding that the majority of the trials are in Phase I, followed by Phase 3 and Phase 2.

Explaining the various phases in the development of a vaccine, E. Sreekumar, chief scientific officer at the Rajiv Gandhi Centre for Biotechnology (RGCB) in Kerala, said Phase 1 trials are small-scale, usually involving few participants, to assess whether the vaccine is safe for humans. Phase 2 trials often involve several hundred subjects, and mainly evaluate the efficacy.

“The final phase involves thousands of people to further assess the efficacy of the vaccine over a defined period of time, and can last several months,” Sreekumar said.

Umashankar Singh, assistant professor, biological engineering, IIT-Gandhinagar told PTI that the number of different approaches employed for COVID-19 are impressive.

“My personal understanding is that all of these strategies will yield results that may suit different profiles of recipients and might end up providing immunity, not exclusively though, against different strains of this virus that will emerge, if not there already,” he said.

The number of COVID-19 cases is close to five million in 188 countries and region with more than 3,23,000 fatalities.—  PTI