Hormone that protects women from liver cancer

LONDON: Researchers have discovered that a hormone—present at higher levels in women—can keep them away from liver cancer, suggesting the disease is more common in men.

Hormone that protects women from liver cancer

Liver cancer is the fourth leading cause of cancer-related deaths worldwide.

LONDON

Researchers have discovered that a hormone—present at higher levels in women—can keep them away from liver cancer, suggesting the disease is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body's metabolism. 

The hormone activates two proteins inside liver cells, known as p38 and AMPK that block cell proliferation and impair tumour growth, said the study, published in the Journal of Experimental Medicine.

"Circulating adiponectin levels have been reported to be higher in women than in men," said Guadalupe Sabio at the Spanish National Center for Cardiovascular Research (CNIC) in Spain. 

Similar to humans, male mice are more also prone to hepatocellular carcinoma (HCC)—the most common form of liver cancer—than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.  

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth. 

Importantly, the study suggested that adiponectin and metformin—a common antidiabetic drug—could be used as novel treatments for liver cancer.

Sabio said that adiponectin's role in HCC is controversial and needed further investigation.

Liver cancer is the fourth leading cause of cancer-related deaths worldwide. — IANS

Top Stories

'Raised issues of principles, don’t crave for any post': Sachin Pilot after meeting Cong leaders

'Raised issues of principles, don’t crave for any post': Sachin Pilot after meeting Cong leaders

Sonia Gandhi to set up panel to address rebel's concerns

UGC questions decision of Maharashtra, Delhi to cancel final-year exams

UGC questions decision of Maharashtra, Delhi to cancel final-year exams

Refuses to relent on September 30 deadline; further hearing ...

Former president Pranab Mukherjee undergoes brain surgery

Former president Pranab Mukherjee undergoes brain surgery

Tests positive for coronavirus, now on ventilator support

Poisonous substance killed Pak migrants: Post mortem; note accuses police of harassment

Poisonous substance killed Pak migrants: Post mortem; note accuses police of harassment

11 Pakistani Hindu migrants were found dead at a farm in Raj...

Sushant Rajput death: Rhea alleges ‘media trial’, urges SC to protect her right to privacy

Sushant Rajput death: Rhea alleges ‘media trial’, urges SC to protect her right to privacy

Opposes transfer of Patna FIR to CBI; says she is being made...

Cities

View All